Already serving forty children the next year, control of the home was conveyed to a newly formed board.

Then known as the "Island City Protestant-Israelite Orphans Home," the board re-organized in 1880 as a Protestant entity, with Moritz Kopperl chairing and Hallie Patrick Jack Ballinger serving as director.

The original Gothic revival building was constructed from 1894-1895 with funding from Henry Rosenberg.

It was destroyed by the storm of 1900 and newspaper publisher William Randolph Hearst hosted a charity bazaar at the Waldorf-Astoria Hotel in New York City to raise funds for a rebuild.

J.P. Bryan, a retired Texas oilman, purchased the Galveston Orphans Home on October 11, 2013 and thoroughly restored the building.