[1] Gambling, Gods and LSD is a "travel diary" that loosely documents director Peter Mettler's "introspective journey" through four countries: Canada, the United States, Switzerland and India.

[7][9] In the next segment petroglyphs and snakes are observed in Monument Valley in Southwestern United States,[10] and time is spent in Las Vegas, where gamblers are scrutinized at their slot machines and poker tables.

[12] Mettler approached Gambling, Gods and LSD with four themes in mind: "transcendence, the denial of death, our relationship to nature and the illusion of safety".

[12] He investigated the fringe cultures of Toronto, Las Vegas, Zurich and Southern India, and said the film is about finding what people's addictions are, what they do to escape reality and give meaning to their lives.

[4] Stephen Lan, writing in Take One: Film & Television in Canada, commended director Mettler's "three-hour epic" for making viewers "think for themselves".

Lan described Gambling, Gods and LSD as a "visual and aural enigma" and said that it is "boldly unique" because of its elusiveness, prompting audiences to form their own interpretations and decide for themselves what the film is all about.

He compared the film to Man with a Movie Camera (1929, Dziga Vertov), Koyaanisqatsi (1982, Godfrey Reggio) and Baraka (1992, Ron Fricke).

[5] Jamie Russell at BBC Online said the film is "agonisingly tedious viewing" and that it "mimics the mind-altering, flattened out monotony of an acid trip".

[6] Source: Swiss Films[1] A soundtrack of Gambling, Gods and LSD by various artists and produced by Peter Mettler was released on CD in 2003.