The Gamkaberg Nature Reserve is situated in the Little Karoo region of the Western Cape province, South Africa.

The Gamka River begins far to the north in the arid Great Karoo and flows southwards towards the ocean.

Four of the Cape biomes occur in the Gamkaberg: Fynbos, Succulent Karoo, Subtropical Thicket, and Evergreen Forest.

Accommodation in the nature reserve includes eco-lodges and a campsite, as well as several remote stone shelters in the mountains, which are remains of herders' huts.

In addition to the animal and plant life, the reserve has an information centre, hiking and 4x4 routes, educational trails, labyrinth, as well as picnic and barbecue facilities.