He is best known for taking part in a number of military expeditions to conquer the Western Regions, over the Pamir Mountains and reaching as far as the Talas River.
Historical records state that Gao Xianzhi was neither muscular nor particularly strong like other army officers and his father was constantly concerned about his son's poor health.
He successively served under the jiedushi Tian Renwan (田仁琬) and Gai Jiayun (蓋嘉運), but received no further promotions.
Tian Renwan, Gai Jiayun, and Fumeng Lingcha had all tried to attack Lesser Bolü in the past, but were unable to defeat it.
In 747, Gao Xianzhi led a three-pronged attack of 10,000 cavalry soldiers, surprising both Lesser Bolü and its Tibetan garrisons.
Xuanzong, in response, summoned Fumeng back to the capital Chang'an in the new year of 748 and promoted Gao to take over his position.
Gao arrested several of Fumeng's subordinates for attacking him—fellow deputy military governor Cheng Qianli (程千里), and army officers Bi Sichen (畢思琛) and Wang Tao (王滔)—but then released them and allowed them to continue serving under him.
[6] As a result of Gao's first successful campaign, Tang began to contend for influence with the Abbasid Caliphate and Tibetan Empire in the area of modern northern Pakistan and Afghanistan.
In late 749, Shilidaqieluo (失里怛伽羅), a prince of the Tuhuoluo (吐火羅, possibly Tocharians), reported to Tang that the king of Qieshi (朅師, the present day Chitral valley in Northern Pakistan), had been aligned with Tufan in pinning down Chinese forces stationed at Lesser Bolü, and suggested that Emperor Xuanzong send forces the region.
Gao also personally profited from the looting in battle—a large supply of diamonds, several camel-loads of gold, prized horses, and other treasures.
In spring 751, Gao personally visited Chang'an, and, for his contributions, Xuanzong gave him the honorific title Kaifu Yitong Sansi (開府儀同三司) and was poised to move him to Hexi where the jiedushi An Sishun resisted to be ousted.
[3] Gao was then made a commanding general of the imperial guards and Wang Zhengjian replaced him as jiedushi of Anxi.
Gao gathered 50,000 soldiers from the Chang'an region and took up position at Shang Commandery (陝郡, roughly modern Sanmenxia, Henan).