Gao Zhizhou (高智周; 602–683) was a Chinese politician of the Tang dynasty, serving as chancellor during the reign of Emperor Gaozong.
Further, he and two other officials, He Kai (賀凱) and Wang Zhenru (王真儒), assisted in Li Hong's studies.
Gao was subsequently recalled to serve as the prefect of Shou Prefecture (壽州, roughly modern Lu'an, Anhui).
In 671, he was recalled to the central government to serve as imperial consultant and acting deputy minister of ceremonies.
In 680, when Li Xian, who had by now lost the favor of Emperor Gaozong's powerful wife Empress Wu (later known as Wu Zetian), was accused of plotting treason, Gao, along with the chancellors Xue Yuanchao and Pei Yan, were in charge of the investigations, and Li Xian was found guilty, deposed, and exiled.