Breeding has aimed at introducing flower heads in varied colours and shapes while retaining the shrubby habit of Argyranthemum.

[1] The cultivar 'Supa594' (Summersong White) has flower heads in which no central disc is visible, as all florets have ray-like petals.

Three main crosses have been documented:[1] The hybrid between A. frutescens and G. coronaria, named ×Glebianthemum valinianum, was discovered in Chile where both parents were naturalized and grew together.

[1] The purpose of making such crosses was to produce more varied flower colours and forms along with desirable plant growth habits.

Colours such as orange and reddish brown, not seen in the parents, were obtained by crossing Argyranthemum cultivars with either Ismelia carinata or Glebionis coronaria.

[14] Because modern cultivars are often the end product of many generations of multiple crosses, determining their origin and so tracing their development is difficult.

[1] Genetic markers were able to distinguish the different intergeneric hybrids and showed that cultivars with similar characteristics shared parents.

[15][16] Two naturally occurring taxa and the following cultivars have gained the Royal Horticultural Society's Award of Garden Merit:[17]