Lyon-Saint-Paul is a railway station in the 5th arrondissement of Lyon, France.

It is located in the area of the same name at the northern end of the Vieux Lyon quarter, between the base of the Fourvière hill and the river Saône.

The station is a terminus for local trains serving the western suburbs of the city.

In addition to upgrades to passenger amenities, the 28 apartments on the second, third and fourth floors were renovated and re-opened in 2013.

The station is served by two Tram-Train services operated by TER Auvergne-Rhône-Alpes.