It was released on DVD and Blu-ray Disc in the United States on June 16, 2009, by 20th Century Fox Home Entertainment, while it was pre-sold overseas by sales representative Velvet Octopus.

It was released theatrically in 3-D in select countries such as Poland, Italy and Spain, and became the most profitable film in the trilogy.

On the planet Dorkon, Professor Wally shows Emperor Jon his new invention, the Moscram ray gun, a device powered by the Klopman crystal that can scramble inanimate objects and organisms into new creatures under the user's control, but the Emperor is more concerned about finding a wife to continue the royal line.

Soon a warship led by Vetvix lands outside the palace and Emperor Jon instantly falls in love with her, asking if he can marry her.

Garzooka and his team then go off to fight Vetvix, and head technician Eli saves Garfield, but Jon gets zombified.

Eli and Garfield find survivors: inventor Wally Stegman, his wife, Bonita, and assistant director Betty.

Emperor Jon and Professor Wally break free, and take over the ship, flying into the air, making Vetvix fall off.

Upon returning to the studio, Garfield uses the Moscram to combine Vetvix with a happiness invention, turning her into a good guy.

Garzooka gives Nermal an Abnermal costume before leaving with Vetvix, Emperor Jon, and Professor Wally, the latter vowing to destroy the Moscram after reversing the damage on Dorkon.

[1] Joly Herman of Common Sense Media gave the film a 1 out of 5 star review, stating: "Kids who love Garfield are better off checking out the TV series or even the live-action movie".