The Gauliga Berlin-Brandenburg was the highest football league in the provinces of Brandenburg and Berlin in the German state of Prussia from 1933 to 1945.

Shortly after the formation of the league, the Nazis reorganised the administrative regions in Germany, and the Gaue Brandenburg and Berlin replaced the Prussian provinces.

In 1939–40, the league played in two separate groups of six teams with a home-and-away final at the end to determine the Berlin-Brandenburg champion.

The imminent collapse of Nazi Germany in 1945 gravely affected all Gauligas and football in the Berlin-Brandenburg region ceased in early 1945 with most clubs having played 13 of their 20-season games and the Berliner SV 92 leading the field.

In Brandenburg, like most of Germany, football took longer to reestablish itself and the regions clubs eventually became part of the new DDR-Oberliga.