The Gauliga Hessen was the highest football league in the German state of Hesse and the Prussian province of Hesse-Nassau from 1933 to 1945.

Shortly after the formation of the league, the Nazis reorganised the administrative regions in Germany, and the Gau Electoral Hesse replaced the Prussian province and the Peoples State.

The region it covered was never particularly successful in German football and this didn't change with the establishment of the Gauliga.

The imminent collapse of Nazi Germany in 1945 gravely affected all Gauligas and football in Hessen ceased in early 1945 with none of the groups having absolved their full program.

In the US occupation zone, which the newly created federal state of Hessen was part of, the Oberliga Süd was formed in late 1945, to replace this league.