Gayane Khachaturian (Armenian: Գայանե Խաչատրյան, Georgian: გაიანე ხაჩატურიანი) (May 9, 1942 – May 1, 2009) was a Georgian-Armenian painter and graphic artist.

She met Sergei Parajanov in 1967 at Elene Akhvlediani's house and they maintained a close friendship which lasted until his death.

Some of Khachaturian’s works are permanently exhibited at the Yerevan Museum of Modern Art, the National Gallery of Armenia, Sergei Parajanov Museum in Yerevan as well as are in a number of private collections, including those owned by Valerie Khanukaev, Bagrat Nikogosyan, and Artashes Aleksanyan.

According to Russian art critic Vitaly Patsyukov, "Khachaturian is among those pioneers of new artistic consciousness who draw into their focus all phenomenal aspects of European 'actual view' and the radical sensuousness and natural freedom of plastic gesture.

Gayane Khachaturian's first informal solo exhibition was at the Skvoznyachok Café in Yerevan in 1967 by the invitation of Sergei Parajanov.