Gayle Mill is a census-designated place (CDP) in Chester County, South Carolina, United States.

[7] U.S. Route 321, which bypasses Chester, passes from north to southeast through the center of Gayle Mill, crossing South Carolina Highway 9, which leads east into the center of the city and west towards Spartanburg.

According to the United States Census Bureau, the Gayle Mill CDP has a total area of 0.66 square miles (1.7 km2), all of it land.

There were 477 housing units at an average density of 711.7 per square mile (274.8/km2).

28.4% of all households were made up of individuals, and 12.4% had someone living alone who was 65 years of age or older.