Great Falls is a town in Chester County, South Carolina, United States and is located fourteen miles southwest of Lancaster, South Carolina.

The Great Falls Depot, Great Falls Downtown Historic District, and Republic Theater are listed on the National Register of Historic Places.

[5] The town council of Great Falls was the defendant-respondent found to have violated the Establishment Clause through their invocation of Christian prayer before meetings.

As of the 2020 United States census, there were 1,951 people, 730 households, and 454 families residing in the town.

30.9% of all households were made up of individuals, and 17.2% had someone living alone who was 65 years of age or older.