Gaylesville is a town in Cherokee County, Alabama, United States.

[2] Gaylesville is named for George W. Gayle, an Alabama politician.

According to the U.S. Census Bureau, the town has a total area of 0.35 square miles (0.9 km2), all land.

There were 65 housing units at an average density of 187.1 per square mile (72.2/km2).

24.6% of all households were made up of individuals, and 13.1% had someone living alone who was 65 years of age or older.