Among students studying at Nagpur University in her days, Sane was the first female to receive a bachelor's degree in the faculty of Science.
In 1927, while she was in college, a Muslim male student with the last name Khan and a Hindu female student with the last name Panandikar got married, and there was a furor, expressed by conservatives especially in the then-influential Marathi daily Pune Waibhawa (पुणें वैभव), about the interfaith marriage.
She advocated that married women in Maharashtra do away with the strong social custom of their placing on their foreheads a kuṅkūṃ dot and wearing a mangalsootra as symbols of their holy matrimonial state.
In the late 1920s, Sane's future husband Dhagamwar had been an active participant in the Indian freedom movement, and the then British government ruling over India had charged him with participation in the 1929 Meerat conspiracy.
Sane's daughter Vasudha Dhagamwar has a law degree, and is a journalist and a civil liberties activist.