The film stars Lance Henriksen, Amy Hathaway, John Savage, Brian Krause and Dave Vescio.

Meanwhile, Lisa (Amy Hathaway), a special agent for the DEA witnesses what she thinks is the death of her best friend, Manning (John Savage), during a drug raid.

After a discussion with Colonel Cencula (Lance Henriksen) it comes to light that Lisa's sister also worked on the alien investigation but was killed through unknown circumstances (later revealed to be due to a mistaken overdose of the serum they're trying to develop), and that Lisa was chosen because of the natural psychic/telepathic link she shared with her twin sister.

Meanwhile, Colonel Cencula, Manning, and the doctor are working together to try and develop a serum to control people using the alien's telepathic technology.

He then calls for a full evacuation of the island and releases the large alien, forcing Doctor Bainbridge to control 'Spike' to pursue Lisa.

Meanwhile, somewhere below, in a somewhat cryptic scene, Dr. Bainbridge is seen rowing down a river with a metal suitcase and what appears to be the comatose body of Lisa's twin sister.