[1][2] Gen-Z for Change has received significant news coverage for its activities, including a one-hour briefing with the White House for 30 prominent TikTok content creators about the United States’ strategic goals regarding the Russian invasion of Ukraine (which was parodied by Saturday Night Live),[3][4] protests against companies such as Starbucks and Kroger for anti-union firings,[5] and abortion-rights advocacy following the U.S. Supreme Court's decision to overturn Roe v. Wade in June 2022.

Olivia Julianna, one of Gen-Z for Change's political strategists, raised more than $2 million in donations to abortion funds across the country through the organization after U.S. Representative Matt Gaetz ridiculed her appearance in July 2022.

[9] In early March 2022, the presidency of Joe Biden enlisted Gen-Z for Change to help organize a briefing between senior administration officials and prominent social media influencers about the Russo-Ukrainian War.

[10][11] Prior to that, Gen-Z for Change partnered with the White House and United States Department of Health and Human Services to combat COVID-19 misinformation and promote vaccination efforts.

[9] In late 2023, Gen-Z por el Cambio was established as a section dedicated to Latino and Latin American perspectives on issues like immigration.