Gene regulatory circuit

[1] [2][3] They are functional clusters of genes that impact each other's expression through inducible transcription factors and cis-regulatory elements.

[7] Genetic regulatory circuits also have an ability to be evolutionarily rewired without the loss of the original transcriptional output level.

[12][13] When designing a synthetic circuit for a specific engineering task, a model is useful for identifying necessary connections and parameter operating regimes that give rise to a desired functional output.

Similarly, when studying a natural circuit, one can use the model to identify the parts or parameter values necessary for a desired biological outcome.

[15][16] By engineering genetic regulatory circuits, cells can be modified to take information from their environment, such as nutrient availability and developmental signals, and react in accordance to changes in their surroundings[17][18] .