A botched mission in Phnom Penh, Cambodia that results in a fatality leads to the disbanding of a CIA Global Response team led by Jake Alexander (Steven Seagal) and whose remaining members include Sonia Dekker (Sonia Couling), Tom Benton (Byron Gibson), Maria Lopez (Mica Javier), and Ben Harrison (Jai Day).

Against CIA Agent Jessica Thompson's orders, the team continues their hunt for arms dealer Gino Orsetti (Edoardo Costa), with the financial assistance of Hong Kong-based magnate Katarina Sokolov (Evgeniya Akhremenko).

While in Bangkok, Tom secures a meeting with Orsetti by posing as an interested buyer in the organs he offers for sale.

Meanwhile, CIA Agent Alec Hayes (Robert Rownd) unsuccessfully dispatches a hitman to assassinate Alexander and thus prevent his team from carrying on with their illegal mission.

General Commander was originally envisaged and marketed as a television series following "a top-secret, rogue international paramilitary unit that fights major criminal organisations in a bid to stop World War III", based on a screenplay by Philipe Martinez and Bey Logan and produced by SPI International and Saradan Media.