General Holmes Drive is a 5-kilometre (3.1 mi) major divided road located in Sydney, New South Wales, Australia.

[3] The road forms major links with the Southern Cross Drive and the M5 East, both part of the Sydney Orbital Network.

The road is named in honour of William Holmes, a distinguished Australian general who died in action during World War I.

The road crosses over the Cooks River via the Endeavour Bridge, continues southeast into the suburbs of Kyeemagh and Brighton-Le-Sands, before terminating at the junction with The Grand Parade that carries traffic towards Sutherland and Wollongong.

It was replaced by National Route 1 from Southern Cross Drive to Brighton-Le-Sands when Sydney Harbour Tunnel opened in 1992, then by Metroad 1 in 1993.