It was established in 1987 and is published twice monthly by Cold Spring Harbor Laboratory Press in association with The Genetics Society.

[4] Over 1999–2004, the journal was ranked fifth in the "Molecular Biology and Genetics" category according to ScienceWatch, with an average of 47 citations per paper.

[5] All issues are available online via the journal website as PDFs, with a text version additionally available from August 1997.

Since 1989, the editor-in-chief has been Terri Grodzicker (Cold Spring Harbor Laboratory).

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