A company, Omnica Corporation, creates sentient robots called omnics, as a result of global research on artificial intelligence (AI).

[1] Technological advances over time lead to these omnics taking over many tasks, making life easier for the human population.

[4] Prior to Genesis, Blizzard had released animated "cinematic" short films that often centered on the lore of a specific character.

[11] Story elements are often noted by media outlets as being largely absent from the video games, with Blizzard having stated they intentionally sought to incorporate a transmedia storytelling method to the franchise, with such story elements previously disseminated through the aforementioned animated shorts, but also through comics and other literary media.

[7] Scott Duwe of The Daily Dot commented on the trailer for Genesis, calling it "freakishly timely" due to the presence of "helpful AI that turned on humanity".