The most predominant denominations among residents in Gentry County who adhere to a religion are Southern Baptists (46.29%), United Methodists (18.20%), and Disciples of Christ (13.12%).

Gentry County is part of the 2nd district in the Missouri House of Representatives, currently held by J. Eggleston (R-Maysville).

Gentry County, along with the rest of the state of Missouri, is represented in the U.S. Senate by Josh Hawley (R-Columbia) and Roy Blunt (R-Strafford).

Like most rural areas throughout northwest Missouri, voters in Gentry County generally adhere to socially and culturally conservative principles which tend to influence their Republican leanings.

On the Democratic side, former Vice President Joe Biden (D-Delaware) both won statewide and carried Gentry County by a wide margin.

Incumbent President Donald Trump (R-Florida) faced only nominal opposition in the primary and won both Gentry County and statewide by large margins.

Businessman Donald Trump (R-New York) narrowly won the state overall and carried a plurality of the vote in Gentry County.

On the Democratic side, former Secretary of State Hillary Clinton (D-New York) both won statewide by a small margin but narrowly lost Gentry County to Senator Bernie Sanders (I-Vermont).

Senator Rick Santorum (R-Pennsylvania), who finished first in the state at large, but eventually lost the nomination to former Governor Mitt Romney (R-Massachusetts).

In 2008, the Missouri Republican Presidential Primary was closely contested, with Senator John McCain (R-Arizona) prevailing and eventually winning the nomination.

Then-Senator Hillary Clinton (D-New York) received more votes than any candidate from either party in Gentry County during the 2008 presidential primary.

Despite initial reports that Clinton had won Missouri, Barack Obama (D-Illinois), also a Senator at the time, narrowly defeated her statewide and later became that year's Democratic nominee, going on to win the presidency.