[1][2] He is the great-great-grandson of Wilhelm II, the last German Emperor and King of Prussia, who abdicated and went into exile upon Germany's defeat in World War I in 1918.

Georg Friedrich is the only son and eldest child of Louis Ferdinand Prinz von Preussen (1944–1977) and Countess Donata of Castell-Rüdenhausen (1950–2015).

[5] He attended grammar schools in Bremen and Oldenburg and completed his education at Glenalmond College near Perth, Scotland, where he passed his A-levels.

[9] In 2018 he moved from a house near Bremen, where he had also spent his childhood, to Babelsberg, a district of Potsdam, the capital city of the German state of Brandenburg.

[13] His position as sole heir to the estate of his grandfather was challenged by his uncles, Friedrich Wilhelm and Michael, who filed a lawsuit claiming that, despite their renunciations as dynasts at the time of their marriages,[5] the loss of their inheritance rights based on their selection of spouse was discriminatory and unconstitutional.

[22] This sparked a public debate about the legitimacy of these claims and the role of the Hohenzollern during and before the Nazi regime in Germany, specifically Crown Prince Wilhelm's involvement.

[23][24][25] On 9 March 2023, Georg Friedrich dropped the suit, hoping that doing so would "open the way for an unencumbered historical debate on the role of my family in the 20th Century following the end of the monarchy.

"[26] In June 2019, a claim made by Georg Friedrich that Rheinfels Castle be returned to the Hohenzollern family was dismissed by a court.