Misch attempted to further develop Dilthey's life-philosophical hermeneutics, in particular in relation to the study of logic, comparative philosophy and autobiography.
Misch concluded his studies with Dilthey in Berlin in 1900 with a dissertation on Die philosophische Begründung des Positivismus in den Schriften von D’Alembert und Turgot.
He worked as a professor in Marburg and Göttingen before retiring under pressure from the National Socialist government in 1935.
Georg Misch wrote one of the first extended critical appropriations of Edmund Husserl and Martin Heidegger, which evaluated phenomenology from the perspective of Dilthey's philosophy, in Lebensphilosophie und Phänomenologie.
Eine Auseinandersetzung der Diltheyschen Richtung mit Heidegger und Husserl, Leipzig 1930 (3.