From 1888 to 1891, he worked in the judge's asylum in Berlin-Pankow and then in the internal medicine department of the Urban Hospital in Berlin under Albert Fraenkel.
[4] On 24 February 1903 Georg Puppe was appointed as Extraordinarius and Director of the newly created Institute of Forensic Medicine at the University of Königsberg in the succession of Karl Seydel.
In 1921 he took over as successor to Adolf Lesser as the director of the Institute of Forensic Medicine at the Silesian Frederick William University in Wroclaw, which he held until his death.
[6] In addition to his involvement in legislative procedures, such as the raising of the penalty limit of the Juvenile Court Act, newly adopted on 16 February 1923, to 14 years and the publication of numerous contributions and textbooks, he was also co-editor of the "Journal of Forensic Medicine."
His most well-known discovery is the Puppe's rule, which allows the sequence of impacts of a blunt object on the human skull to be determined by means of an analysis of the fracture edges.