He graduated from the Tbilisi Real School in 1887 and the St. Petersburg Mining Institute in 1892.

In 1890, he founded the Union of Georgian and Armenian Students in St. Petersburg, which soon disbanded.

In 1892, with the participation of Dekanozishvili, the political organization of Georgian students of the Russian Empire - the "Liberty League" -[1] was founded in Kutaisi.

In 1901, George Dekanozishvili, together with Archil Jorjadze, Tedo Sakhokia, Kita Abashidze, Andria Dekanozishvili, Giorgi Laskhishvili and others, founded the Georgian Socialist-Federalist Revolutionary Party.

In 1901, under his leadership, a periodical of the party was founded in Paris - the newspaper Sakartvelo, which was published together with the French version (La Géorgie) until the end of 1905.