George Douglas Wise (June 4, 1831 – February 4, 1908) was an American slave owner,[1] white supremacist, and U.S. Representative from Virginia.

He studied law in the College of William and Mary, Williamsburg, Virginia.

He served as captain in the Confederate States Army during the Civil War.

Presented credentials as a Member-elect to the Fifty-first Congress and served from March 4, 1889, to April 10, 1890, when he was succeeded by Edmund Waddill, Jr., who contested his election.

He served as chairman of the committee on Interstate and Foreign Commerce (Fifty-second and Fifty-third Congresses).