George Duffield (October 7, 1732 – February 2, 1790) was a leading eighteenth-century Presbyterian minister.

He did personal study and ministerial preparation in theology with the guidance of Dr. Robert Smith, of Pequea, Pennsylvania.

His ordination to Presbyterian ministry led him to serve three churches in central Pennsylvania in Carlisle, Newville, and Dillsburg.

From the fall of 1772 until his death in 1790, he served as pastor at the Old Pine Street Presbyterian Church in Philadelphia.

His grandson was George Duffield IV, also a Presbyterian minister; and his great-grandson was George Duffield V, the American Presbyterian minister and hymnodist, who was a pastor from 1840 to 1869 at numerous cities in Pennsylvania, New Jersey, New York, and Michigan; known for authoring Stand Up, Stand Up for Jesus.