George Frederick Whitworth (March 15, 1816 – October 6, 1907[1]) was an American Presbyterian missionary, educated at Hanover College in Indiana.

Whitworth worked as a minister in the Ohio Valley until 1853, when he and his family moved to the Western frontier.

[3][4][5] He was active in the founding of the first church in Grand Mound, Washington, which he co-pastored with J. W. Goodell (father of pioneer Phoebe Judson).

His grave is an American Presbyterian and Reformed Historic Site (No.

252) registered by the Presbyterian Historical Society, headquartered in Philadelphia.