Most recently, she is serving as the inaugural Chief Executive Officer and President of Colorado Longitudinal Study.

Starting in 2005, Wise served as provost and vice president for academic affairs at the University of Washington.

[6] She led the establishment of a unique engineering-driven college of medicine aimed toward training the next generation of doctors to use technology and big data to develop new materials, new devices, new imaging, and new robotics to provide better medical care to more people at lower cost.

[7][8] In August 2015, Wise resigned the chancellorship at Urbana-Champaign, and, shortly after, university administrators released emails Wise had hidden from Illinois Freedom of Information Act requests regarding the Steven Salaita hiring controversy.

[11] She serves on the RAND Health,[12] the Robert Wood Johnson Foundation,[13] and Colorado Children's Hospital boards of directors.