Genovese began his major league career on April 29, 1950, appearing as a pinch hitter for pitcher Ray Scarborough.

[3] He pinch ran for catcher Al Evans in his third and final game (May 6), scoring a run when Eddie Yost doubled him home two batters later.

Genovese managed the Batavia Clippers (1952), St. Jean Canadians (1953), Hutchinson Elks (1954), Salinas Packers (1954), Tigres del México (1955–1958), Artesia Giants (1960) and El Paso Sun Kings (1961–1963).

[5] Covering Southern California for the Giants from 1964 through 1995, he played a major role in the signing of about 40 players who eventually made the major leagues, including Jim Barr, Bobby Bonds, Jack Clark, Chili Davis, Rob Deer, George Foster, Eric King, Dave Kingman, Garry Maddox, Gary Matthews, Randy Moffitt, Matt Nokes, Matt Williams.

Major League Baseball (MLB) annually conducts the George Genovese Lifetime Achievement Awards.