[1] When he was twelve years old, Guesnon bought a ukulele under the influence of an uncle who played guitar.
He worked in Sam Morgan's band from 1930–35, then played briefly in Monroe, Louisiana with Lou Johnson's Californians.
In 1940 he recorded four songs in New York for Decca in addition to playing with Trixie Smith and Jelly Roll Morton.
He worked for Pullman trains, then enlisted in the Merchant Marines when World War II started.
On several occasions he recorded with Kid Thomas Valentine and performed at Preservation Hall in his native New Orleans.