Hill was selected 26th overall by the San Antonio Spurs in the 2008 NBA draft and would spend three seasons with the team before being traded to the Indiana Pacers in June 2011.

Born and raised in Indianapolis, Indiana, Hill looked up to players like Michael Jordan, Magic Johnson, and Larry Bird while dreaming of one day playing in the NBA;[1] when asked about his goal of becoming a first-round pick in the 2008 NBA draft, Hill commented: "It's my childhood dream".

An only child,[3] Hill attended Broad Ripple High School[4] where he excelled as one of the top high school players in the state and was one of the "Magnificent Seven" from Indianapolis (with Greg Oden, Mike Conley Jr., Josh McRoberts, Rodney Carney, Eric Gordon, and Courtney Lee).

[5] He faced off against Oden and Conley during his junior year in high school, and remembers playing pickup games against 10-year-old Gordon when he was 13.

[6] Despite scholarship offers from several big conference schools, including Temple and Indiana, he chose to commit to IUPUI, wishing to stay with his ailing great-grandfather, Gilbert Edison.

[7] A few months after he agreed to attend IUPUI, his great-grandfather died, never getting the opportunity to see Hill play basketball at the college level.

Although he had regularly attracted NBA scouts to his college games, Hill was not projected in most mock drafts largely due to remaining unannounced.

After an impressive run at the Orlando pre-draft rookie camp, Hill attracted attention and became a projected second-round selection.

[14][15] At the Utah Revue, Hill led his team by averaging 12.9 points over four games; however he continued to struggle offensively with his shooting, only making 21.4% of his three-point field goals.

Hill made two clutch free throws with 6.9 seconds left and then forced a turnover on the defensive end to beat the previously undefeated Atlanta Hawks.

[17][18] In 2008, Hill joined the San Antonio Spurs and made his NBA debut on November 4 against the Dallas Mavericks in the third game of the season.

[20] Hill initially served as the main reserve at point guard, but after Tony Parker suffered an injury early in the season he was promoted to starter.

On April 1, Hill notched career highs of 30 points, 5 steals, and 7 assists in a home game win against the Houston Rockets.

[27] Hill ended the regular season tied at second place with Kevin Durant and Marc Gasol for the Most Improved Player of the Year award.

During their first-round playoff series against the Orlando Magic, Hill scored double-digits in all five games as the Pacers advanced to the Eastern Conferences Semifinal.

Facing the Miami Heat in the Conference Semifinals, Hill scored a playoff high 20 points and 5 assists in game 3.

Hill and the Pacers appeared in the Eastern Conference Finals, but lost to the defending champion Miami Heat in 7 games.

[34] After missing the first 28 games of the season with a left knee injury, Hill returned to action on December 23 against the New Orleans Pelicans.

[37] On February 19, 2016, Hill had nine points and nine assists and matched a career-high with 11 rebounds in the Pacers' 101–98 win over the Oklahoma City Thunder.

[39] He made his debut for the Jazz in their season opener on October 25 against the Portland Trail Blazers, recording 19 points and six assists in a 113–104 loss.

[41] On November 23, he scored 22 points in his return from an eight-game absence, as the Jazz snapped a four-game losing streak with a 108–83 win over the Denver Nuggets.

Smith, apparently confused and, thinking the Cavaliers were winning, attempted to dribble out the clock before realizing his error and frantically passing to George Hill with 1.2 seconds left, in front of a visibly irate LeBron James.

[49] Hill and the Bucks appeared in the Eastern Conference Finals (the franchise's first since 2000–01), but were defeated in 6 games by the eventual champion Toronto Raptors.

Hill was integral in organizing a wildcat strike of players during the 2020 NBA bubble in response to the shooting of Jacob Blake and other instances of police violence.

On November 24, 2020, Hill was traded to the Oklahoma City Thunder in a four team deal also involving the New Orleans Pelicans and Denver Nuggets.

[58] On May 7, Hill returned to Milwaukee's rotation, playing 11 minutes during a 103–101 Game 3 win over the Boston Celtics in the second round.