George II of Hesse-Darmstadt, German: Georg II von Hessen-Darmstadt (17 March 1605, in Darmstadt – 11 June 1661) was the Landgrave of Hesse-Darmstadt from 1626 to 1661.

He married Sophia Eleonore of Saxony on 1 April 1627.

From 1645 to 1648 he led the so-called Hessenkrieg against the Landgravine Amalie Elizabeth of Hesse-Kassel over the inheritance of the extinct line of Hesse-Marburg.

This conflict resulted in the loss of Hesse-Marburg to Hesse-Kassel.

This article about a member of the German nobility is a stub.