After the death of his father in 1547, George II inherited the Duchy of Brzeg (which included the towns of Oława, Strzelin, Niemcza, Kluczbork, Byczyna, Wołów and Ścinawa).

In 1548, the early death of his relative Henry II of Poděbrady, made him the regent of his Duchy of Oleśnica on behalf of his sons Henry III and Charles II until 1569.

George II became in the regent of the Duchy on behalf of his nephew, jointly with Balthasar von Promnitz, until 1556, when Frederick III managed to return to Legnica and retake the power.

During all his reign he maintain a good relationship to the Habsburgs (despite being a Lutheran) and was sent by the Emperor in some diplomatic missions.

10 August 1527 – d. Brzeg, 2 January 1595), daughter of Joachim II Hector, Elector of Brandenburg.