George Kleine (1864 – June 8, 1931) was an American film producer and distributor and cinema pioneer.

Klein's father, Charles, was a New York optician who sold optical devices and stereopticons.

He founded Kalem Company, an American film studio in New York City in 1907 with Samuel Long,[2] and Frank J. Marion.

Klein was involved in the company for only a short period of time; however, it was a profitable investment for him, as his partners were soon successful enough to buy out his shares at a considerable premium.

Kleine was a national distributor of silent movies in the 1910s, a notable example being Essanay Studios 1918 film, “Men Who Have Made Love to Me” starring Mary MacLane.