The George Leatherbury House was a historic house along the shore of Portersville Bay, halfway between Bayou La Batre and Bayou Coden, in southern Mobile County, Alabama.

It was built in 1912 by George Scarborough Leatherbury in the local "Bay house" style.

The house was added to the National Register of Historic Places on June 14, 1990.

[1] It was subsequently destroyed on August 29, 2005, by an estimated record-level 12-to-16-foot (3.7 to 4.9 m) storm surge generated by Hurricane Katrina.

This article about a property in Alabama on the National Register of Historic Places is a stub.