William George Lee (November 2, 1873 – February 10, 1927) was an American college football player and medical doctor.

He played for the Harvard Crimson football team while attending Harvard Medical School and was a consensus selection at the guard position on the 1901 College Football All-America Team.

Lee began his college education at Northwestern University.

He played at the left guard position for the 1901 Harvard Crimson football team that compiled an undefeated 12–0 record and outscored its opponents 205 to 44.

[5] After Harvard defeated rival Yale, 22–0, the Boston Daily Globe praised Lee's work:"[T]here is no lad in that Harvard eleven to whom I would sooner take off my hat to than to George Lee.