George Middleton (October 14, 1800 in Philadelphia, Pennsylvania – December 31, 1888 in Allentown, New Jersey) was an American Democratic Party politician who represented New Jersey's 2nd congressional district from 1863 to 1865.

He became a tanner and moved to Allentown, where he held several local offices.

He served as a member of the New Jersey General Assembly in 1858 and 1859.

Middleton was elected as a Democrat to the Thirty-eighth Congress, serving in office from March 4, 1863 – March 3, 1865, but was an unsuccessful candidate for reelection in 1864 to the Thirty-ninth Congress.

After leaving Congress, he resumed the business of tanning.