He has been performing and recording with wide range of artists including Soul Rebels Brass Band, Dr. John, Paul McCartney, Robbie Robertson, Willy DeVille, Robert Palmer, Patti LaBelle, Jimmy Buffett, David Byrne, Johnny Adams, Harry Connick Jr., Earl King, Warren Haynes, Tori Amos, and Snooks Eaglin among many others.

He grew up in New Orleans next to future Meters bandmate, Joe "Zigaboo" Modeliste, and the two became friends when George was 10 years old.

After a short time, however, the band was trimmed down to four core members - Art Neville, Zigaboo Modeliste, Leo Nocentelli and Porter Jr.

The four were playing six nights a week at a Bourbon Street bar called Ivanhoe when they were approached by Allen Toussaint and asked if they wanted to sign a record deal.

Also in the 1990s, Porter became a highly coveted bass player in the studio playing with artists like David Byrne and Tori Amos.

In 2012, Porter, Leo Nocentelli, Joe Modeliste, and Phish keyboardist Page McConnell performed two concerts as The Metermen.

Porter appears in performance footage in the 2005 documentary film Make It Funky!, which presents a history of New Orleans music and its influence on rhythm and blues, rock and roll, funk and jazz.

[12] In the film, he performs with Snooks Eaglin and house band on "Come On (Let the Good Times Roll)", and is seen in clips with other musicians, including Art Neville.

[13] Since Hurricane Katrina, Porter has done some activist work with other New Orleans musicians informing people of the dangers of eroding wetlands threatening the future of the city.

On February 24, 2018, Porter sat in with Dead & Company during their New Orleans concert at the Smoothie King Center, playing bass on several songs including "Smokestack Lightning", "Bertha" and taking lead vocals on "Sugaree".