He has appeared on recordings by Bob Dylan, Robbie Robertson, Edie Brickell, Willie Nelson, Dr. John and The New Orleans Social Club among others.

Neville is interviewed on screen and appears in performance footage with The Neville Brothers in the 2005 documentary film Make It Funky!, which presents a history of New Orleans music and its influence on rhythm and blues, rock and roll, funk and jazz.

The Soul Rebels' name was conceived by Neville at the New Orleans venue Tipitina's, where the band was opening.

[6] As a member of the Neville Brothers, Cyril won the 1989 Grammy Award for Best Pop Instrumental Performance for the song "Healing Chant".

[8] In 1996, he and his brothers were nominated for the Grammy Award for Best Pop Performance by a Duo or Group with Vocals for the song "Fire on the Mountain".