In 1799, Pryme entered Trinity College, Cambridge, winning a scholarship there in 1800 and graduating with a Bachelor of Arts in 1803.
[1] In 1804, he began studying law at Lincoln's Inn, and was called to the Bar in 1806, practising in London until health problems forced him to return to Cambridge in 1808.
[3] In 1828, he was made Professor of Political Economy by the university senate, although a chair was not established for the topic at Cambridge until just before his retirement.
[4] He was politically active, and successfully opposed parliamentary candidates sponsored by the Duke of Rutland, and eventually winning a seat in the House of Commons representing Cambridge as a Whig in 1832.
In 1870, his memoirs were published, Autobiographic Recollections of George Pryme, edited by his daughter Alicia Bayne.