Sandford was the third son of Henry Sandford by the Honourable Sarah Moore, daughter of The 1st Viscount Mountcashell.
He was returned to the Irish House of Commons for both Carrick and Roscommon in 1783, but chose to sit for the latter.
[1] In 1800 his elder brother Henry was elevated to the Peerage of Ireland as Baron Mount Sandford, with a special remainder to his younger brothers William and George.
[2] George's nephew Henry succeeded to the barony in 1814 but was killed at a brawl at Windsor on his way to the Ascot races in 1828, when the title devolved on George.
Lord Mount Sandford died in September 1846, aged 90, when the barony became extinct.