George Semple (c. 1700 – 13 April 1782) was a notable Irish builder and architect.
His earliest known work is the steeple, 103 feet (31.4 m) in height, of St. Patrick's Cathedral, Dublin, which he designed and erected in 1749.
He also built St Patrick's Hospital (1749–57), which was founded in 1747 with money bequeathed by Jonathan Swift following his death in 1745.
Semple later wrote a book, Treatise on Building in Water, first published in 1776, which was based on this project.
In 1777 Semple was living in Queen Street, Dublin, where he died late in 1781 or early in 1782.