His father, the 5th Lord Seton was killed at the battle of Flodden and George's mother survived her husband by 45 years till 1558, managing the family's interests.
When George came of age Janet joined the Convent of St Catherine at Sciennes in Edinburgh.
Like many Scottish nobles he gave his assent to the marriage proposed between Mary, Queen of Scots and Prince Edward of England in 1543.
He died in 1549, and was first buried at Culross Abbey as Seton Collegiate Church was in the occupied zone during the war of the Rough Wooing.
They were put on trial in Tolbooth at Edinburgh, on the charge that their letters denied the authority of James VI of Scotland and his representatives.