Sir George Simeon (c.1584 – 4 May 1664) was an English landowner and politician who sat in the House of Commons between 1614 and 1624.
Simeon was the son of John Simeon of Brightwell Baldwin, Minigrove, Britwell Priory, Chilworth, and Stoke Talmage in Oxfordshire and his wife Anne Molyns, daughter of Anthony Molyns.
In 1611 he sold "The Howe" to his brother, later Sir John Simeon.
After entering Gray's Inn in 1616 to study law he was re-elected MP for Wallingford in 1621 and in 1624.
Simeon married secondly, Margaret Molyneux, daughter of Sir Richard Molyneux, 1st Baronet of Sefton, Lancashire and was succeeded by the youngest and only surviving son of five.