The second son of Thomas Richard Spence, a surgeon of Hanover Square, London, he was educated at a private school at Richmond, Surrey, and at the University of Glasgow, where he matriculated in 1802, and graduated M.A.
After some time spent in the office of a London solicitor, he was admitted in 1806 a student at the Inner Temple, where he was called to the bar on 28 June 1811; he was then elected a bencher in 1835, reader in 1845, and treasurer in 1846.
[1] A pupil of the equity draughtsman John Bell, Spence rapidly acquired an extensive practice, most of which he lost on taking silk (27 December 1834).
[1] Spence was an early activist for legal education, and an original member of the Society for promoting the Amendment of the Law, founded in 1844.
He was also author of:[1] Spence married, in 1819, Anne Kelsall, daughter of a solicitor of Chester, who with issue survived him.