He then became a British Library Visiting Research Fellow at the Postgraduate School of Librarianship and Information Science at the University of Sheffield, as a colleague of Peter Willett.
[1] In 1976, Vladutz moved to the United States and joined the Institute for Scientific Information (ISI) in Philadelphia as a senior research associate.
In 1981, he became manager for basic research at ISI, directing projects in automatic indexing and retrieval, including the development of bibliographic coupling techniques for associative searching of large journal citation files.
[2][6] According to Ugi et al., Vladutz impacted the development of chemoinformatics from 1960 onward through his introduction of computer- and database-oriented chemical structure and reaction organization, in addition to the retrieval of same.
These ideas were particularly influential to Elias James Corey and co-workers, who created the chemical synthesis program LHASA at the Harvard University in 1967.