George Washington Manypenny (1808 – July 15, 1892) was the Commissioner of Indian Affairs of the United States from 1853 to 1857.

[3] In 1853, Manypenny was a competitor at the Democratic State Convention for governor, but lost the nomination to William Medill.

[3] Manypenny was appointed as Commissioner of Indian Affairs during the administration of President Franklin Pierce, serving from 1853 to 1857.

[2] He held the position of special Indian commissioner under appointments by Presidents Grant, Hayes and Garfield.

[2][5] In 1876 Manypenny was appointed chair of a special commission to investigate the issues that led to the Sioux outbreak that year, which included the defeat of the American forces under George Armstrong Custer at the battle of the Little Bighorn.

Her brother-in-laws included William Kennon Sr., Hugh J. Jewett, Wilson Shannon and Isaac E. Eaton.

He had at least five children, including Willie, Elizabeth/Bettie, Lewis, Sallie and Burnham W.[1][2][3] Manypenny lived at a three-story house on North Fourth Street in Zanesville.